BDBM50271663 CHEMBL4129034

SMILES C[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2CC2CC2)C(=O)NC2CCS(=O)(=O)CC2)c2ccccc12)C(F)(F)F

InChI Key InChIKey=FMKRUXVKAZQWTL-UHFFFAOYSA-N

Data  1 IC50  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50271663   

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50271663(CHEMBL4129034)
Affinity DataKd:  11nMAssay Description:Binding affinity to recombinant human RORgamma LBD (237 to 497 residues) expressed in Escherichia coli BL21 (DE3) GOLD by 1,8-ANS dye-based thermoflu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50271663(CHEMBL4129034)
Affinity DataIC50: 6.10nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50271663(CHEMBL4129034)
Affinity DataEC50:  58nMAssay Description:Inverse agonist activity at RORgammat in human whole blood assessed as reduction in IL17A productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-beta(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50271663(CHEMBL4129034)
Affinity DataKd: >6.90E+4nMAssay Description:Binding affinity to recombinant human RORbeta LBD (201 to 452 residues) expressed in Escherichia coli BL21 (DE3) GOLD by 1,8-ANS dye-based thermofluo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed