BDBM50270876 3-((E)-2-Biphenyl-3-yl-vinyl)-4'-fluoro-biphenyl-4-carboxylic acid::CHEMBL485891

SMILES OC(=O)c1ccc(cc1\C=C\c1cccc(c1)-c1ccccc1)-c1ccc(F)cc1

InChI Key InChIKey=VNOQAHWKTBHYAB-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50270876   

TargetBcl2-associated agonist of cell death(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50270876(3-((E)-2-Biphenyl-3-yl-vinyl)-4'-fluoro-biphenyl-4...)
Affinity DataIC50: 6.90E+3nMAssay Description:Binding affinity to BH3 binding groove of BclXLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Taros Chemicals

Curated by ChEMBL
LigandPNGBDBM50270876(3-((E)-2-Biphenyl-3-yl-vinyl)-4'-fluoro-biphenyl-4...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 15 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed