BDBM50268295 2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-indol-3-yl)-acrylamide::CHEMBL483059

SMILES CCCCCCCCNC(=O)C(=C\c1cn(CCCN(C)C)c2ccccc12)\C#N

InChI Key InChIKey=MYIMRONQBLZJFI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50268295   

TargetDynamin-1(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50268295(2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-in...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of dynamin 1-mediated endocytosis internalization of Tf-A594 in human U2OS cells pretreated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDynamin-2(Rat)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50268295(2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-in...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of rat full length His6-tagged dyn2 using phosphatidylserine as substrate after 90 mins by malachite green GTPase assay in presence of GTPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDynamin-2(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50268295(2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-in...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of dyn2 in human U2OS cells assessed as clathrin-mediated endocytosis of Tfn after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDynamin-1(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50268295(2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-in...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of phosphotidylserine liposome-stimulated Dynamin 1 (unknown origin) GTPase activity by malachite green assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed