BDBM50268134 CHEMBL4097093

SMILES ONC(=O)c1ccc(CN2CCN(CC2)C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)cc1

InChI Key InChIKey=UYHSCMQSBJXZGX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50268134   

TargetPoly [ADP-ribose] polymerase 2(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50268134(CHEMBL4097093)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells using biotinylated substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50268134(CHEMBL4097093)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged PARP1 expressed in baculovirus infected Sf9 cells using biotinylated substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50268134(CHEMBL4097093)
Affinity DataIC50: 17nMAssay Description:Inhibition of HDAC6 (unknown origin) using acetylated peptide substrate preincubated for 15 mins followed by substrate addition measured after 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50268134(CHEMBL4097093)
Affinity DataIC50: 503nMAssay Description:Inhibition of HDAC1 (unknown origin) using acetylated peptide substrate preincubated for 15 mins followed by substrate addition measured after 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50268134(CHEMBL4097093)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of PARP1 (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed