BDBM50267480 4-{[(4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione::CHEMBL477064

SMILES CCCOc1cnc(CNC=C2C(=O)NC(=O)c3ccc(I)cc23)cc1O

InChI Key InChIKey=DXMZEMWEDCPBNA-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50267480   

TargetCyclin-dependent kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267480(4-{[(4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of CDK2/Cyclin E assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267480(4-{[(4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino...)
Affinity DataIC50: 2.53E+4nMAssay Description:Inhibition of CDK1/Cyclin B1 assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267480(4-{[(4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino...)
Affinity DataIC50: 30nMAssay Description:Inhibition of CDK4/Cyclin D1 assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50267480(4-{[(4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino...)
Affinity DataIC50: 501nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50267480(4-{[(4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50267480(4-{[(4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino...)
Affinity DataIC50: 290nMAssay Description:Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [ga...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50267480(4-{[(4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino...)
Affinity DataIC50: 71nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50267480(4-{[(4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as su...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50267480(4-{[(4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino...)
Affinity DataIC50: 38nMAssay Description:Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in pres...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50267480(4-{[(4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed