BDBM50267255 4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]-6-iodo-4Hisoquinoline-1,3-dione::CHEMBL504547

SMILES Oc1cc(CNC=C2C(=O)NC(=O)c3ccc(I)cc23)ccc1-c1ccoc1

InChI Key InChIKey=CUISPPCDYZFGCY-UHFFFAOYSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50267255   

TargetProtein kinase C theta type(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: 2.59E+4nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of Tpl2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BrafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of STAT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of LYNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRetinoblastoma-associated protein(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: 610nMAssay Description:Inhibition of retinoblastoma susceptibility gene product phosphorylation in human MCF7 cells after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: 60nMAssay Description:Inhibition of CDK4/Cyclin D1 assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: 2.44E+4nMAssay Description:Inhibition of CDK1/Cyclin B1 assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of CDK2/Cyclin E assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed