BDBM50266786 CHEMBL4063337

SMILES NCc1ccnc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)c1

InChI Key InChIKey=BKRZYDXKJLEFCP-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50266786   

TargetLysyl oxidase homolog 2(Human)
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50: 110nMAssay Description:Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed
TargetLysyl oxidase homolog 2(Mouse)
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant mouse LOXL2 expressed in mouse whole blood assessed as reduction of H2O2 production from oxidative deamination of DAP prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of CYP2C9 human liver microsomes after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed
TargetLysyl oxidase homolog 2(Rat)
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50: 120nMAssay Description:Inhibition of rat LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed
TargetLysyl oxidase homolog 2(Human)
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50: 710nMAssay Description:Inhibition of recombinant human LOXL2 expressed in human whole blood assessed as reduction of H2O2 production from oxidative deamination of DAP prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed
TargetLysyl oxidase homolog 2(Human)
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50: 74nMAssay Description:Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed
TargetLysyl oxidase homolog 3(Human)
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of recombinant human LOXL3 assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed
TargetProtein-lysine 6-oxidase(Human)
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of human LOX expressed in HEK cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed