BDBM50265873 7-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)isoindolin-1-one::CHEMBL517163

SMILES COc1cc2CCN(C(=O)CN(C)C)c2cc1Nc1nc(Nc2cccc3CNC(=O)c23)c2cc[nH]c2n1

InChI Key InChIKey=KTQGBACJIGNCAB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50265873   

TargetInsulin-like growth factor 1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265873(7-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265873(7-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin...)
Affinity DataIC50: 16nMAssay Description:Inhibition of IGF1R phosphorylation by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50265873(7-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of PI3KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265873(7-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed