BDBM50265039 (1E,4E)‐1,5‐bis(4‐tert‐butylphenyl)penta‐1,4‐dien‐3‐ one (8)::(1E,4E)-1,5-Bis(4-tert-butylphenyl)penta-1,4-dien-3-one::1,5-bis(4-tert-butylphenyl)penta-1,4-dien-3-one::CHEMBL498590

SMILES CC(C)(C)c1ccc(\C=C\C(=O)\C=C\c2ccc(cc2)C(C)(C)C)cc1

InChI Key InChIKey=QJZGSPYLQCUEQD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50265039   

TargetPhospholipase A2(Human)
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia

LigandPNGBDBM50265039(CHEMBL498590 | 1,5-bis(4-tert-butylphenyl)penta-1,...)
Affinity DataIC50: 5.19E+4nMpH: 8.0 T: 2°CAssay Description:Substrate 1,2-bis(heptanoylthio)-glycerophosphocholine and human recombinant PLA2-V were resuspended in assay buffer, and DTNB was dissolved in an aq...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2014
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia

LigandPNGBDBM50265039(CHEMBL498590 | 1,5-bis(4-tert-butylphenyl)penta-1,...)
Affinity DataIC50: 5.32E+4nMpH: 8.0 T: 2°CAssay Description:Reaction mixture containing 100 mM Tris-HCl buffer (pH 8) and COX-1 (ovine) or COX-2 (human recombinant) was preincubated for 10 min in a water bath ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2014
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia

LigandPNGBDBM50265039(CHEMBL498590 | 1,5-bis(4-tert-butylphenyl)penta-1,...)
Affinity DataIC50: 3.70E+4nMpH: 7.0 T: 2°CAssay Description:The assay buffer contained 100 mM KHPO4 (pH 7.0), 2 mM EDTA and 2.5 mM reduced GSH. 100 µL of reaction buffer containing human recombinant mPGES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2014
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50265039(CHEMBL498590 | 1,5-bis(4-tert-butylphenyl)penta-1,...)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50265039(CHEMBL498590 | 1,5-bis(4-tert-butylphenyl)penta-1,...)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed