BDBM50264567 CHEMBL4063074

SMILES Cc1cc(C)cc(c1)C1CCCN1Cc1ccc(Oc2ccc(cc2F)C(N)=O)cc1

InChI Key InChIKey=ZHPMYDSXGRRERG-UHFFFAOYSA-N

Data  6 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50264567   

TargetMu-type opioid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264567(CHEMBL4063074)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at recombinant human mu-opioid receptor expressed in CHO cell membranes assessed as inhibition of DAMGO-induced [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264567(CHEMBL4063074)
Affinity DataIC50: 6.70nMAssay Description:Antagonist activity at recombinant human kappa-opioid receptor expressed in CHO cell membranes assessed as inhibition of U69593-induced [35S]GTPgamma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2020
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264567(CHEMBL4063074)
Affinity DataIC50: 96nMAssay Description:Antagonist activity at recombinant human delta-opioid receptor expressed in HEK293 cell membranes assessed as inhibition of DPDPE-induced [35S]GTPgam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264567(CHEMBL4063074)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at human mu opiod receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS binding incubated for 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264567(CHEMBL4063074)
Affinity DataIC50: 7.70nMAssay Description:Antagonist activity at human kappa opiod receptor expressed in CHO cells assessed as inhibition of U69593-induced [35S]GTPgammaS binding incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264567(CHEMBL4063074)
Affinity DataIC50: 109nMAssay Description:Antagonist activity at human delta opiod receptor expressed in human HEK293 cells assessed as inhibition of DPDPE-induced [35S]GTPgammaS binding incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264567(CHEMBL4063074)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]U69593 from recombinant human kappa-opioid receptor expressed in CHO cell membranes after 60 mins by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264567(CHEMBL4063074)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]-U69593 from human kappa opiod receptor expressed in CHO cells incubated for 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264567(CHEMBL4063074)
Affinity DataKi:  91nMAssay Description:Displacement of [3H]DAMGO from recombinant human mu-opioid receptor expressed in CHO cell membranes after 60 mins by liquid scintillation counting me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2020
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264567(CHEMBL4063074)
Affinity DataKi:  92nMAssay Description:Displacement of [3H]DPDPE from recombinant human delta-opioid receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264567(CHEMBL4063074)
Affinity DataKi:  94nMAssay Description:Displacement of [3H]-DAMGO from human mu opiod receptor expressed in CHO cells incubated for 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264567(CHEMBL4063074)
Affinity DataKi:  105nMAssay Description:Displacement of [3H]-DPDPE from human delta opiod receptor expressed in human HEK293 cells incubated for 60 mins by liquid scintillation counting met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed