BDBM50264423 CHEMBL4103171

SMILES CNC(=O)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NC)cccc2c1

InChI Key InChIKey=QNMAPJPZQPPOIL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50264423   

Target26S proteasome non-ATPase regulatory subunit 14(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264423(CHEMBL4103171)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in beta5 inhibitor MG132 pretreated human HeLa cells expressing UbG76...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
TargetSTAM-binding protein(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264423(CHEMBL4103171)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of AMSH (unknown origin) using DiUbK63TAMRA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264423(CHEMBL4103171)
Affinity DataIC50: 6.80E+4nMAssay Description:Inhibition of CSN5 (unknown origin) using SCFskp2-Nedd8OG as substrate after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
Target26S proteasome non-ATPase regulatory subunit 14(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264423(CHEMBL4103171)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed