BDBM50264417 CHEMBL4104719

SMILES O=C(NCc1ccncc1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCc3ccncc3)cccc2c1

InChI Key InChIKey=AAEFWTWIEWZGDE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50264417   

Target26S proteasome non-ATPase regulatory subunit 14(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264417(CHEMBL4104719)
Affinity DataIC50: 200nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
TargetSTAM-binding protein(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264417(CHEMBL4104719)
Affinity DataIC50: 500nMAssay Description:Inhibition of AMSH (unknown origin) using DiUbK63TAMRA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264417(CHEMBL4104719)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CSN5 (unknown origin) using SCFskp2-Nedd8OG as substrate after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
Target26S proteasome non-ATPase regulatory subunit 14(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264417(CHEMBL4104719)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in beta5 inhibitor MG132 pretreated human HeLa cells expressing UbG76...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed