BDBM50263293 2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone::2-methyl-3-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)quinazolin-4(3H)-one::CHEMBL476373

SMILES Cc1nc2ccccc2c(=O)n1-c1ccc(OCCCN2CCCC2)cc1

InChI Key InChIKey=PEXQMYKPVANJKN-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50263293   

TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263293(2-methyl-3-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataIC50: 3.5nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263293(2-methyl-3-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-6-yl]meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263293(2-methyl-3-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataIC50: 1.70nMAssay Description:Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263293(2-methyl-3-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human ERG in HEK293 cells assessed as inhibition of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihyd...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263293(2-methyl-3-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263293(2-methyl-3-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataIC50: 1.70nMAssay Description:Antagonist activity at H3R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistamine H3 receptor(Human)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263293(2-methyl-3-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataKi:  1.09nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed