BDBM50261729 6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)quinoline::CHEMBL468176

SMILES Fc1ccc(-c2noc(n2)C2CCN(CC2)c2cnc3ccc(Cl)cc3c2)c(Cl)c1

InChI Key InChIKey=KZPYBMNBUZPMKP-UHFFFAOYSA-N

Data  10 IC50  13 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50261729   

TargetHistamine H1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50:  7nMAssay Description:Agonist activity at human CB2 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human CB2 receptor assessed as inhibition of forskolin-induced increase in intracellular cAMPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at dopamine D2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at adrenergic beta-1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50:  1.43E+3nMAssay Description:Agonist activity at human CB1 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at sst4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of dopamine D2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of adrenergic beta-1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSomatostatin receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of sst4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataIC50: 500nMAssay Description:Displacement of radiolabeled dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCannabinoid receptor 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >2.00E+3nMAssay Description:Agonist activity at human CB1 receptor assessed as inhibition of forskolin-induced increase in intracellular cAMPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed