BDBM50261077 CHEMBL4072883

SMILES Fc1cc(NC[C@H]2CCCOC2)c(Cl)cc1S(=O)(=O)Nc1nccs1

InChI Key InChIKey=CUKXCYUCHNHBBC-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50261077   

TargetSodium channel protein type 5 subunit alpha(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50261077(CHEMBL4072883)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of human Nav1.5 inactivated state form expressed in HEK293 cells at -50 mV holding potential by by automated patch clamp electrophysiology...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50261077(CHEMBL4072883)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50261077(CHEMBL4072883)
Affinity DataIC50: 78nMAssay Description:Inhibition of human recombinant Nav1.7 inactivated state form expressed in HEK293 cells at -60 mV holding potential by manual patch clamp electrophys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50261077(CHEMBL4072883)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant CYP3A4 expressed in baculovirus-infected insect cells using 7-Benzoyloxy-4-trifluoromethyl coumarin substrate in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50261077(CHEMBL4072883)
Affinity DataIC50: 54nMAssay Description:Inhibition of mouse recombinant Nav1.7 inactivated state form expressed in HEK293 cells at -60 mV holding potential by manual patch clamp electrophys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2020
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50261077(CHEMBL4072883)
Affinity DataIC50: 76nMAssay Description:Inhibition of human Nav1.5 inactivated state form expressed in HEK293 cells at -60 mV holding potential by by automated patch clamp electrophysiology...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50261077(CHEMBL4072883)
Affinity DataIC50: 34nMAssay Description:Inhibition of Nav1.7 in adult mouse DRG neurons assessed as inhibition of fast-inactivating TTX-sensitive sodium currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2020
Entry Details Article
PubMed