BDBM50260047 CHEMBL4096754

SMILES Cc1cc(COc2cc(OS([O-])(=O)=O)cc3oc(cc(=O)c23)-c2ccc(OS([O-])(=O)=O)cc2)c(C)cc1COc1cc(OS([O-])(=O)=O)cc2oc(cc(=O)c12)-c1ccc(OS([O-])(=O)=O)cc1

InChI Key InChIKey=QMSMQZNWPOGVKQ-UHFFFAOYSA-J

Data  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50260047   

TargetPlasminogen(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260047(CHEMBL4096754)
Affinity DataKd:  1.90E+3nMAssay Description:Binding affinity to human plasmin assessed as loss of intrinsic tryptophan fluorescence at 250 uM by spectrofluorometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed
TargetPlasminogen(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260047(CHEMBL4096754)
Affinity DataIC50: 2.00E+4nMAssay Description:Allosteric inhibition of full length human plasmin by using chromogenic substrate spectrozyme PL preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed
TargetPlasminogen(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260047(CHEMBL4096754)
Affinity DataKd:  5.40E+3nMAssay Description:Binding affinity to human dansyl-EGR-chloromethylketone-plasmin complex assessed as loss of intrinsic tryptophan fluorescence by spectrofluorometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260047(CHEMBL4096754)
Affinity DataIC50: 9.13E+4nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed