BDBM50260046 CHEMBL4060852

SMILES [O-]S(=O)(=O)Oc1ccc(cc1)-c1cc(=O)c2c(OCC=CCOc3cc(OS([O-])(=O)=O)cc4oc(cc(=O)c34)-c3ccc(OS([O-])(=O)=O)cc3)cc(OS([O-])(=O)=O)cc2o1

InChI Key InChIKey=QSHKRVQXWPBZFZ-UHFFFAOYSA-J

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50260046   

TargetPlasminogen(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260046(CHEMBL4060852)
Affinity DataIC50: 1.21E+5nMAssay Description:Allosteric inhibition of full length human plasmin by using chromogenic substrate spectrozyme PL preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed
TargetPlasminogen(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260046(CHEMBL4060852)
Affinity DataKd:  3.60E+3nMAssay Description:Binding affinity to human plasmin assessed as loss of intrinsic tryptophan fluorescence at 250 uM by spectrofluorometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50260046(CHEMBL4060852)
Affinity DataIC50: 4.76E+4nMAssay Description:Inhibition of human neutrophil elastase using S1384 as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed