BDBM50259155 (Z)-Hymenialdisine::Hymenialdisine

SMILES NC1=NC(=O)\C(N1)=C1/CCNC(=O)c2[nH]c(Br)cc12

InChI Key InChIKey=ATBAETXFFCOZOY-UHFFFAOYSA-N

Data  26 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50259155   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 35nMAssay Description:Inhibition of CK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Rat)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant recombinant rat GSK3beta using GS-1 peptide as substrate in presence of [gamma-32P]ATP measured after 30 mins incubation by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of topoisomerase 2 alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDNA topoisomerase 1(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of topoisomerase 1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of c-abl (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of c-Src (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-Raf (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 42nMAssay Description:Inhibition of Chk2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of Chk1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetG1/S-specific cyclin-D2(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 700nMAssay Description:Inhibition of CDK6/Cyclin D2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 25nMAssay Description:Inhibition of CDK5/p25 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 600nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetCasein kinase II subunit alpha 3(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Jamia Hamdard (Hamdard University)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 10nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2019
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 500nMAssay Description:Inhibition of Protein kinase C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 6nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 1(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Erk2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 3(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 470nMAssay Description:Inhibition of Erk1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK3/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 70nMAssay Description:Inhibition of CDK2/Cyclin A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 40nMAssay Description:Inhibition of CDK1/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 22nMAssay Description:Inhibition of CDK1/Cyclin B (unknown origin) in presence of gamma32P-ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant Plasmodium falciparum GSK3 using GS-1 as substrate measured after 30 mins in presence of [gamma 32P-ATP] by SDS-PAGE based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details Article
PubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 23nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Jamia Hamdard (Hamdard University)

Curated by ChEMBL
LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 10nMAssay Description:Inhibition of GSK3beta (unknown origin) expressed in Sf9 cells using GS1 as substrate and [gamma32]ATP after 30 min by scinitllation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50: 30nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article