BDBM50254666 CHEMBL479421::N1-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-5-methoxy-N3-((R)-1-phenylethyl)isophthalamide

SMILES COc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC1)C(=O)N[C@H](C)c1ccccc1

InChI Key InChIKey=GKRKKPGYGQZJMG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50254666   

TargetBeta-secretase 1(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50254666(N1-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-pheny...)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of BACE1 expressed in human 293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50254666(N1-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-pheny...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of BACE2 expressed in human 293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed