BDBM50254534 CHEMBL467229::N,N-dibutyl-4-chloro-1-(2-((S)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)phenyl)-5-methyl-1H-pyrazole-3-carboxamide

SMILES CCCCN(CCCC)C(=O)c1nn(c(C)c1Cl)-c1ccccc1C(=O)N1Cc2ccccc2C[C@H]1CO

InChI Key InChIKey=CAKOCBPHBFPMRS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50254534   

TargetApoptosis regulator Bcl-2(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50254534(N,N-dibutyl-4-chloro-1-(2-((S)-3-(hydroxymethyl)-1...)
Affinity DataIC50: 100nMAssay Description:Inhibition of GST fused Bcl-2 binding to biotinylated 16 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50254534(N,N-dibutyl-4-chloro-1-(2-((S)-3-(hydroxymethyl)-1...)
Affinity DataIC50: 780nMAssay Description:Inhibition of GST fused Bcl-2 binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBcl2-associated agonist of cell death(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50254534(N,N-dibutyl-4-chloro-1-(2-((S)-3-(hydroxymethyl)-1...)
Affinity DataIC50: 6.94E+3nMAssay Description:Inhibition of GST fused Bcl-xL binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed