BDBM50253762 CHEMBL4098392

SMILES O=c1[nH]c(CN2CCCC2)nc2cc(sc12)-c1cn[nH]c1

InChI Key InChIKey=OFPLMRKDJFHRSH-UHFFFAOYSA-N

Data  6 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50253762   

TargetRho-associated protein kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50253762(CHEMBL4098392)
Affinity DataIC50: 820nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ROCK1 catalytic domain (1 to 477 residues) expressed in baculovirus expression system using Bio...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCell division cycle 7-related protein kinase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50253762(CHEMBL4098392)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Cdc7 in human HeLa cells assessed as reduction in MCM2 phosphorylation at ser40 residues after 7 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50253762(CHEMBL4098392)
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant human full length Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50253762(CHEMBL4098392)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length human CDC2 (1 to 298 residues)/human N-terminal GST-tagged CyclinE1 (1 to 410 residues) expressed in baculovirus expression...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50253762(CHEMBL4098392)
Affinity DataIC50: 77nMAssay Description:Inhibition of recombinant human full length Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50253762(CHEMBL4098392)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of recombinant human full length Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50253762(CHEMBL4098392)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to recombinant human full length Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovir...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed