BDBM50253469 1-Chloro-3,4-dihydronaphthalene-2-carboxaldehyde guanylhydrazone::2-[(1-chloro-3,4-dihydronaphthalen-2-yl)methylene]hydrazinecarboximidamide::CHEMBL448651

SMILES [#7]\[#6](-[#7])=[#7]\[#7]=[#6]-[#6]-1=[#6](Cl)-c2ccccc2-[#6]-[#6]-1

InChI Key InChIKey=CEQITFVLSUCYGJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50253469   

TargetEstrogen receptor(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50253469(2-[(1-chloro-3,4-dihydronaphthalen-2-yl)methylene]...)
Affinity DataIC50: 5.50E+3nMAssay Description:Binding affinity to ERalpha assessed as inhibition of steroid receptor coactivator interaction in african green monkey COS7 cells by mammalian 2 hybr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50253469(2-[(1-chloro-3,4-dihydronaphthalen-2-yl)methylene]...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of estradiol-induced coactivator peptide SRC binding to recombinant estrogen receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGag polyprotein(Avian erythroblastosis virus (strain ES4))
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50253469(2-[(1-chloro-3,4-dihydronaphthalen-2-yl)methylene]...)
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity at estrogen receptor alpha expressed in human HEC1 cells assessed as inhibition of 1 nM estradiol-induced transcriptional activit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEnvelope glycoprotein gp70(MMTV)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50253469(2-[(1-chloro-3,4-dihydronaphthalen-2-yl)methylene]...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of estradiol-induced coactivator peptide SRC1 binding to estrogen receptor alpha expressed in human HEC1 cells after 24 hrs by luciferase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEnvelope glycoprotein gp160(HIV-1)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50253469(2-[(1-chloro-3,4-dihydronaphthalen-2-yl)methylene]...)
Affinity DataIC50: 2.50E+7nMAssay Description:Displacement of [3H]estradiol from human estrogen receptor alpha/estrogen receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed