BDBM50250963 CHEMBL4076247
SMILES CCc1c(cnc(N)c1-c1ccc(O)cc1)-c1ccc2[nH]ncc2c1
InChI Key InChIKey=ZHYXJQQBKROZDX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50250963
Affinity DataIC50: 980nMAssay Description:Inhibition of full-length native C-terminal USP7 (unknown origin) using Ub-Rho110 as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 750nMAssay Description:Binding affinity to human His-tagged and [15N-13C-2H], delta1[13CH3]-Ile, [13CH3]-Leu/Val and [13CH3]-Met-labeled USP7-catalytic domain (208 to 554 r...More data for this Ligand-Target Pair
Affinity DataEC50: 300nMAssay Description:Inhibition of USP7 in human SJSA cells assessed as increase in ubiquitinated MDM2 level after 16 hrs in presence of MG132 by MSD assayMore data for this Ligand-Target Pair
Affinity DataIC50: 750nMAssay Description:Inhibition of human USP7 using UbA10 as substrate incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human USP7 using ubiquitin-Rho as substrate incubated for 1 hrsMore data for this Ligand-Target Pair