BDBM50250422 (+)-N-methyl-laurotetanine::CHEMBL464099::N-methyllaurotetanine

SMILES COc1cc-2c(C[C@@H]3N(C)CCc4cc(OC)c(OC)c-2c34)cc1O

InChI Key InChIKey=ZFLRVRLYWHNAEC-UHFFFAOYSA-N

Data  15 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50250422   

TargetProlyl endopeptidase(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50250422(N-methyllaurotetanine | (+)-N-methyl-laurotetanine...)
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of POP (unknown origin) using ZGP-AMC as substrate pre treated for 5 mins followed by substrate addition measured after 30 mins by ELISA a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Tom'S of Maine

Curated by ChEMBL
LigandPNGBDBM50250422(N-methyllaurotetanine | (+)-N-methyl-laurotetanine...)
Affinity DataEC50:  160nMAssay Description:Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCholinesterase(Horse)
University of Malaya

Curated by ChEMBL
LigandPNGBDBM50250422(N-methyllaurotetanine | (+)-N-methyl-laurotetanine...)
Affinity DataIC50: 2.19E+5nMAssay Description:Inhibition of equine serum BChE preincubated for 15 mins followed by addition of S-butyrylthiocholine chloride as substrate measured after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50250422(N-methyllaurotetanine | (+)-N-methyl-laurotetanine...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Tom'S of Maine

Curated by ChEMBL
LigandPNGBDBM50250422(N-methyllaurotetanine | (+)-N-methyl-laurotetanine...)
Affinity DataKi:  85nMAssay Description:Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50250422(N-methyllaurotetanine | (+)-N-methyl-laurotetanine...)
Affinity DataKi:  306nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT6 receptor expressed in HEK cell membranes by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Tom'S of Maine

Curated by ChEMBL
LigandPNGBDBM50250422(N-methyllaurotetanine | (+)-N-methyl-laurotetanine...)
Affinity DataKi:  314nMAssay Description:Displacement of [3H]Way100635 from human recombinant 5-HT1A receptor expressed in CHO cell membranes by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50250422(N-methyllaurotetanine | (+)-N-methyl-laurotetanine...)
Affinity DataKi:  323nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cell membranes by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50250422(N-methyllaurotetanine | (+)-N-methyl-laurotetanine...)
Affinity DataKi:  373nMAssay Description:Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membranes by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 5A(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50250422(N-methyllaurotetanine | (+)-N-methyl-laurotetanine...)
Affinity DataKi:  566nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT5A receptor expressed in Flp-In CHO cell membranes by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50250422(N-methyllaurotetanine | (+)-N-methyl-laurotetanine...)
Affinity DataKi: >950nMAssay Description:Displacement of [3H]mesulergine from human recombinant 5-HT2C receptor expressed in Flp-IN HEK cell membranes by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50250422(N-methyllaurotetanine | (+)-N-methyl-laurotetanine...)
Affinity DataKi: >950nMAssay Description:Displacement of [3H]prazosin from human recombinant adrenergic alpha1B receptor expressed in HEKT cell membranes by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50250422(N-methyllaurotetanine | (+)-N-methyl-laurotetanine...)
Affinity DataKi: >950nMAssay Description:Displacement of [3H]rauwolscine from human recombinant adrenergic alpha2C receptor expressed in MDCK cell membranes by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50250422(N-methyllaurotetanine | (+)-N-methyl-laurotetanine...)
Affinity DataKi: >950nMAssay Description:Displacement of [3H]CGP12177 from human recombinant adrenergic beta2 receptor expressed in CHO Flp-In cell membranes by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50250422(N-methyllaurotetanine | (+)-N-methyl-laurotetanine...)
Affinity DataKi: >950nMAssay Description:Displacement of [3H]N-methylspiperone from human recombinant dopamine D3 receptor expressed in HEKT cell membranes by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50250422(N-methyllaurotetanine | (+)-N-methyl-laurotetanine...)
Affinity DataKi: >950nMAssay Description:Displacement of [3H]WIN35428 from human recombinant DAT expressed in HEK cell membranes by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50250422(N-methyllaurotetanine | (+)-N-methyl-laurotetanine...)
Affinity DataKi: >950nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK cell membranes by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50250422(N-methyllaurotetanine | (+)-N-methyl-laurotetanine...)
Affinity DataKi: >950nMAssay Description:Displacement of [3H]citalopram from human recombinant SERT expressed in HEK cell membranes by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed