BDBM50249877 (S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl)benzamido)pentanedioic acid::CHEMBL491104::N-{4-[4-(2-Amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)-butyl]benzoyl}-L-glutamic Acid

SMILES Nc1nc2sc(CCCCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cc2c(=O)[nH]1

InChI Key InChIKey=KVBZUTNKUVNMNN-UHFFFAOYSA-N

Data  1 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50249877   

TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)
Affinity DataIC50: 5.51E+3nMAssay Description:Inhibition of mouse recombinant GARFTaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)
Affinity DataIC50: 13nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of incorporation of [14C]glycine into [14C]formyl GAR after 30 mins in presence of az...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)
Affinity DataIC50: 5.51E+6nMAssay Description:Inhibition of mouse recombinant GARFtase assessed as FGAR formation by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)
Affinity DataIC50: 1.33E+4nMAssay Description:Inhibition of GARFtase in human KB cells assessed as [14C]glycine incorporation in to [14C]FGAR in folate free RPMI medium with 2 nM LCV by in-situas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReduced folate transporter(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-bl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFolate receptor alpha(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTite...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFolate receptor beta(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProton-coupled folate transporter(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)
Affinity DataKi:  9.48E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed