BDBM50249557 2,2'-(2-(pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene)bis(N,N-dimethylaniline)::2-((3-(2-(dimethylamino)benzyl)-2-(pyridin-4-yl)-tetrahydropyrimidin-1(2H)-yl)methyl)-N,N-dimethylbenzenamine::CHEMBL471728

SMILES CN(C)c1ccccc1CN1CCCN(Cc2ccccc2N(C)C)C1c1ccncc1

InChI Key InChIKey=KVQOGDQTWWCZFX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50249557   

TargetSonic hedgehog protein(Mouse)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249557(2-((3-(2-(dimethylamino)benzyl)-2-(pyridin-4-yl)-t...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetZinc finger protein GLI1(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50249557(2-((3-(2-(dimethylamino)benzyl)-2-(pyridin-4-yl)-t...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human Gli1-mediated transcriptional activity in human Rh30 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetZinc finger protein GLI1/GLI2(Mouse)
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50249557(2-((3-(2-(dimethylamino)benzyl)-2-(pyridin-4-yl)-t...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of GLI1/GLI2 in mouse Shh Light2 cells assessed as reduction in endogenous hedgehog signalling in presence of Smo agonist SAG by luciferas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed