BDBM50248967 1-(4-(2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-3-(2-nitrophenyl)urea::CHEMBL475554

SMILES [O-][N+](=O)c1ccccc1NC(=O)Nc1ccc(CCN2CCc3ccccc3C2)cc1

InChI Key InChIKey=LYWURPUUGRPDKS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50248967   

LigandPNGBDBM50248967(1-(4-(2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phe...)
Affinity DataIC50: 8.71E+3nMAssay Description:Inhibition of BCRP expressed in MDCK cells by pheophorbide A assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50248967(1-(4-(2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phe...)
Affinity DataIC50: 6.76E+3nMAssay Description:Inhibition of BCRP expressed in MDCK cells by pheophorbide A assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50248967(1-(4-(2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phe...)
Affinity DataIC50: 770nMAssay Description:Inhibition of P-glycoprotein-mediated multidrug resistance in adriamycin-resistant human A2780/ADR cells by calcein AM assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed