BDBM50248614 CHEMBL4066819
SMILES COCCNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1
InChI Key InChIKey=NENJFZKQHYXRDQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50248614
Affinity DataIC50: 0.990nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 25nMAssay Description:Binding affinity to partial length wild-type human CDK19 (M1 to N360 residues) expressed in bacterial expression system by KINOMEscan assayMore data for this Ligand-Target Pair
Affinity DataKd: 46nMAssay Description:Binding affinity to partial length wild-type human CDK8 (M1 to T360residues) expressed in bacterial expression system by kinome scan assayMore data for this Ligand-Target Pair
Affinity DataKd: 86nMAssay Description:Binding affinity to partial length wild-type human HASPIN (I452 to K798 residues) expressed in bacterial expression system by kinome scan assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 19(Human)
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataKd: 97nMAssay Description:Binding affinity to partial length wild-type human YSK4 (T1019 to H1328 residues) expressed in bacterial expression system by kinome scan assayMore data for this Ligand-Target Pair
Affinity DataKd: >3.00E+3nMAssay Description:Binding affinity to partial length wild-type human EPHA3 (D604 to K889 residues) expressed in bacterial expression system by kinome scan assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.460nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot methodMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataKd: 81nMAssay Description:Binding affinity to full length human DYRK1B (M1 to S629 residues) expressed in bacterial expression system by kinome scan assayMore data for this Ligand-Target Pair
Affinity DataKd: 160nMAssay Description:Binding affinity to partial length human HIPK1 (M146 to I555 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair