BDBM50248431 CHEMBL489125::N-hydroxy-3-(2-phenethyl-1-propyl-1H-benzo[d]imidazol-5-yl)acrylamide::US10201527, Compound 36::US10736881, Compound 36::US8551988, 36

SMILES CCCn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12

InChI Key InChIKey=IKIBXHADESLBBT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50248431   

TargetHistone deacetylase 1(Human)
Mei Pharma

US Patent
LigandPNGBDBM50248431(CHEMBL489125 | US8551988, 36 | N-hydroxy-3-(2-phen...)
Affinity DataIC50: 227nMAssay Description:The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Mei Pharma

US Patent
LigandPNGBDBM50248431(CHEMBL489125 | US8551988, 36 | N-hydroxy-3-(2-phen...)
Affinity DataIC50: 170nMAssay Description:Inhibition of recombinant HDAC1 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Mei Pharma

US Patent
LigandPNGBDBM50248431(CHEMBL489125 | US8551988, 36 | N-hydroxy-3-(2-phen...)
Affinity DataIC50: 227nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Mei Pharma

US Patent
LigandPNGBDBM50248431(CHEMBL489125 | US8551988, 36 | N-hydroxy-3-(2-phen...)
Affinity DataIC50: 227nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
Go to US Patent