BDBM50248429 CHEMBL489709::N-hydroxy-3-(1-(2-morpholinoethyl)-2-phenethyl-1H-benzo[d]imidazol-5-yl)acrylamide::US10201527, Compound 44::US10736881, Compound 44

SMILES ONC(=O)\C=C\c1ccc2n(CCN3CCOCC3)c(CCc3ccccc3)nc2c1

InChI Key InChIKey=JMWCDNZQKRQNGS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50248429   

TargetHistone deacetylase 1(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50248429(N-hydroxy-3-(1-(2-morpholinoethyl)-2-phenethyl-1H-...)
Affinity DataIC50: 270nMAssay Description:Inhibition of recombinant HDAC1 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50248429(N-hydroxy-3-(1-(2-morpholinoethyl)-2-phenethyl-1H-...)
Affinity DataIC50: 268nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Mei Pharma

US Patent
LigandPNGBDBM50248429(N-hydroxy-3-(1-(2-morpholinoethyl)-2-phenethyl-1H-...)
Affinity DataIC50: 345nMAssay Description:To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5×105 cells/well for 24 h. Colo20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50248429(N-hydroxy-3-(1-(2-morpholinoethyl)-2-phenethyl-1H-...)
Affinity DataIC50: 268nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Mei Pharma

US Patent
LigandPNGBDBM50248429(N-hydroxy-3-(1-(2-morpholinoethyl)-2-phenethyl-1H-...)
Affinity DataIC50: 345nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
Go to US Patent