BDBM50248158 CHEMBL450195::N-butylresorcinol::US8993596, 4-Butylresorcinol (Rucinol)::US9422261, 4-Butyl- resorcinol

SMILES CCCCc1ccc(O)cc1O

InChI Key InChIKey=CSHZYWUPJWVTMQ-UHFFFAOYSA-N

Data  2 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50248158   

Target5,6-dihydroxyindole-2-carboxylic acid oxidase(Mouse)
Galderma Research & Development

US Patent
LigandPNGBDBM50248158(N-butylresorcinol | CHEMBL450195 | US8993596, 4-Bu...)
Affinity DataIC50: 3.00E+3nMpH: 6.8 T: 2°CAssay Description:The activity of the inhibitors is measured using a lysate of B16F1 cells (murine melanoma line). In the presence of the L-tyrosine substrate, the tyr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM50248158(N-butylresorcinol | CHEMBL450195 | US8993596, 4-Bu...)
Affinity DataIC50: 1.00E+3nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetPolyphenol oxidase 2(White button mushroom)
Amorepacific

Curated by ChEMBL
LigandPNGBDBM50248158(N-butylresorcinol | CHEMBL450195 | US8993596, 4-Bu...)
Affinity DataIC50: 150nMAssay Description:Inhibition of mushroom tyrosinase activity after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosinase(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50248158(N-butylresorcinol | CHEMBL450195 | US8993596, 4-Bu...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human tyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosinase(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50248158(N-butylresorcinol | CHEMBL450195 | US8993596, 4-Bu...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human tyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosinase(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50248158(N-butylresorcinol | CHEMBL450195 | US8993596, 4-Bu...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50248158(N-butylresorcinol | CHEMBL450195 | US8993596, 4-Bu...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human tyrosinase using L-DOPA as substrate incubated for 10 to 20 mins by MBTH dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTyrosinase(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50248158(N-butylresorcinol | CHEMBL450195 | US8993596, 4-Bu...)
Affinity DataIC50: 1.35E+4nMAssay Description:Inhibition of human His-tagged tyrosinase CD expressed in HEK293 cells assessed as inhibition of melanin production using L-DOPA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTyrosinase(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50248158(N-butylresorcinol | CHEMBL450195 | US8993596, 4-Bu...)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of tyrosinase in human MNT-1 cell lysates using L-DOPA as substrate assessed as reduction in melanin formation preincubated for 10 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosinase(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50248158(N-butylresorcinol | CHEMBL450195 | US8993596, 4-Bu...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of truncated His-tagged human tyrosinase expressed in HEK293 cells using L-DOPA as substrate by MBTH dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosinase(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50248158(N-butylresorcinol | CHEMBL450195 | US8993596, 4-Bu...)
Affinity DataKi:  9.00E+3nMAssay Description:Binding affinity to human His-tagged tyrosinase CD expressed in HEK293 cells assessed as inhibition constant using L-DOPA as substrate by HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTyrosinase(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50248158(N-butylresorcinol | CHEMBL450195 | US8993596, 4-Bu...)
Affinity DataKi:  9.10E+3nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed