BDBM50247634 CHEMBL4067973
SMILES N[C@@H](CCCN(CCc1cccc(c1)C(N)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
InChI Key InChIKey=HSCPXDPGPWYINM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50247634
TargetNicotinamide N-methyltransferase(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human NNMT (1 to 264 residues) expressed in Escherichia coli BL21 (DE3) using nicotinamide/SAM as substrate/co-factor measured for 20 m...More data for this Ligand-Target Pair
3D Structure (crystal)TargetNicotinamide N-methyltransferase(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKd: 2.70E+3nMAssay Description:Binding affinity to human NNMT (1 to 264 residues) expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetric methodMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of DOT1L (unknown origin) after 1 hr by filter-based assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 7(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PRMT7 (unknown origin) using [3H]-SAM as co-factor by scintillation proximity assayMore data for this Ligand-Target Pair
TargetN-lysine methyltransferase SMYD2(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of SMYD2 (unknown origin) using [3H]-SAM as co-factor by scintillation proximity assayMore data for this Ligand-Target Pair
TargetRNA 5'-monophosphate methyltransferase(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of BCDIN3D (unknown origin) using [3H]-SAM as co-factor by scintillation proximity assayMore data for this Ligand-Target Pair
TargetNicotinamide N-methyltransferase(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 4.36E+3nMAssay Description:Inhibition of wild-type human full length NNMT expressed in Escherichia coli BL21(DE3) cells assessed as reduction in 1-methyl-nicotinamide formation...More data for this Ligand-Target Pair
TargetNicotinamide N-methyltransferase(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKi: 89nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
TargetNicotinamide N-methyltransferase(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKi: 89nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair