BDBM50247556 CHEMBL4104117

SMILES ONC(=O)c1ccc(CNc2cccc3cccnc23)cc1

InChI Key InChIKey=BPDQUKCPNSRTTR-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50247556   

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50247556(CHEMBL4104117)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SIRT1 (1 to 747 end residues) expressed in Escherichia coli using Ac-RHK-K(Ac)-AMC as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 11(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50247556(CHEMBL4104117)
Affinity DataIC50: 376nMAssay Description:Inhibition of recombinant human N-terminal Strep2-tagged HDAC11 (1 to 347 residues) expressed in baculovirus infected insect cells using Boc-Lys(TFA)...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50247556(CHEMBL4104117)
Affinity DataIC50: 9.79E+3nMAssay Description:Inhibition of human HDAC10 using RHKKAc as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 9(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50247556(CHEMBL4104117)
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of HDAC9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 8(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50247556(CHEMBL4104117)
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged/N-terminal Strep2-tagged HDAC8 (1 to 377 residues) expressed in insect cells using RHK-K(Ac)-AM...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 7(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50247556(CHEMBL4104117)
Affinity DataIC50: 709nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HDAC7 (518 to 991 residues) expressed in insect cells using Boc-K(TFA)-AMC as substrate after 6...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50247556(CHEMBL4104117)
Affinity DataIC50: 7.75E+3nMAssay Description:Inhibition of full length recombinant human C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 (395 to 489 residues) expressed in insect cells u...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 2(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50247556(CHEMBL4104117)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of full length recombinant human C-terminal GST-tagged HDAC2 expressed in baculovirus infected insect cells using RHK-K(Ac)-AMC as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50247556(CHEMBL4104117)
Affinity DataIC50: 9.55E+3nMAssay Description:Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected sf21 cells using RHK-K(Ac)-AMC as subs...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50247556(CHEMBL4104117)
Affinity DataIC50: 0.291nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus infected insect cells using RHK-K(Ac)-AMC as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 5(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50247556(CHEMBL4104117)
Affinity DataIC50: 3.11E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC5 (656 to 1122 residues) expressed in insect cells using Boc-K(Ac)-AMC as substrate after 6...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50247556(CHEMBL4104117)
Affinity DataIC50: 4.44E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged/N-terminal GST-tagged HDAC4 (627 to 1084 residues) expressed in insect cells using Boc-K(Ac)-AM...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50247556(CHEMBL4104117)
Affinity DataIC50: 9.55E+3nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50247556(CHEMBL4104117)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50247556(CHEMBL4104117)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed