BDBM50247539 CHEMBL472915::N-((3S,5S)-1-((E)-3-(3,4-dimethoxyphenyl)acryloyl)-5-(hydroxycarbamoyl)pyrrolidin-3-yl)nicotinamide::N-((3S,5S)-1-(3-(3,4-dimethoxyphenyl)acryloyl)-5-(hydroxycarbamoyl)pyrrolidin-3-yl)nicotinamide

SMILES COc1ccc(\C=C\C(=O)N2C[C@H](C[C@H]2C(=O)NO)NC(=O)c2cccnc2)cc1OC

InChI Key InChIKey=AKOSAZUQCGCWJD-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50247539   

TargetAminopeptidase N(Pig)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50247539(N-((3S,5S)-1-((E)-3-(3,4-dimethoxyphenyl)acryloyl)...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of pig kidney microsomal APN using L-Leu-p-nitroanilide as substrate preincubated for 5 mins before substrate addition measured after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50247539(N-((3S,5S)-1-((E)-3-(3,4-dimethoxyphenyl)acryloyl)...)
Affinity DataIC50: 4.38E+4nMAssay Description:Inhibition of MMP2 in human SKOV3 cell suspension using succinylated gelatin as substrate preincubated for 10 mins before substrate addition measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50247539(N-((3S,5S)-1-((E)-3-(3,4-dimethoxyphenyl)acryloyl)...)
Affinity DataIC50: 950nMAssay Description:Inhibition of MMP2 (unknown origin) using succinylated gelatin as substrate preincubated for 10 mins before substrate addition measured after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50247539(N-((3S,5S)-1-((E)-3-(3,4-dimethoxyphenyl)acryloyl)...)
Affinity DataIC50: 9nMAssay Description:Inhibition of MMP2 by microtiter plate fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50247539(N-((3S,5S)-1-((E)-3-(3,4-dimethoxyphenyl)acryloyl)...)
Affinity DataIC50: 1.42E+5nMAssay Description:Inhibition of aminopeptidase N by microtiter plate fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50247539(N-((3S,5S)-1-((E)-3-(3,4-dimethoxyphenyl)acryloyl)...)
Affinity DataIC50: 9nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50247539(N-((3S,5S)-1-((E)-3-(3,4-dimethoxyphenyl)acryloyl)...)
Affinity DataIC50: 1.42E+5nMAssay Description:Inhibition of aminopeptidase NMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50247539(N-((3S,5S)-1-((E)-3-(3,4-dimethoxyphenyl)acryloyl)...)
Affinity DataIC50: 9nMAssay Description:Inhibition of MMP2 by microtiter plate fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50247539(N-((3S,5S)-1-((E)-3-(3,4-dimethoxyphenyl)acryloyl)...)
Affinity DataIC50: 1.42E+5nMAssay Description:Inhibition of APN by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50247539(N-((3S,5S)-1-((E)-3-(3,4-dimethoxyphenyl)acryloyl)...)
Affinity DataIC50: 5.64E+3nMAssay Description:Inhibition of gelatinase A (unknown origin) after 30 mins using succinylated gelatin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
TargetAminopeptidase N(Pig)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50247539(N-((3S,5S)-1-((E)-3-(3,4-dimethoxyphenyl)acryloyl)...)
Affinity DataIC50: 1.17E+5nMAssay Description:Inhibition of porcine microsomal aminopeptidase N preincubated for 30 mins using L-Leu-p-nitroanilide as substrate by UV-VIS spectrophotometerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50247539(N-((3S,5S)-1-((E)-3-(3,4-dimethoxyphenyl)acryloyl)...)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50247539(N-((3S,5S)-1-((E)-3-(3,4-dimethoxyphenyl)acryloyl)...)
Affinity DataIC50: 266nMAssay Description:Inhibition of recombinant human MMP2 catalytic domain (Tyr110 to Asp452 residues) preincubated for 45 mins followed by Mea-Pro-Leu-Gly-Leu-Dap(Dnp)-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50247539(N-((3S,5S)-1-((E)-3-(3,4-dimethoxyphenyl)acryloyl)...)
Affinity DataIC50: 360nMAssay Description:Inhibition of recombinant human MMP9 (Phe107 to Pro449 residues) expressed in Escherichia coli preincubated for 45 mins followed by Mea-Pro-Leu-Gly-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed