BDBM50246927 CHEMBL4060447::US10570121, Example 127

SMILES COC(C1CCOC1)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl

InChI Key InChIKey=AZFROWZIMGUVBM-UHFFFAOYSA-N

Data  4 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50246927   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50246927(CHEMBL4060447 | US10570121, Example 127)
Affinity DataIC50: 391nMAssay Description:Inhibition of EZH2 in human KARPAS422 cells assessed as reduction in H3K27me3 level after 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50246927(CHEMBL4060447 | US10570121, Example 127)
Affinity DataIC50: 391nMAssay Description:Inhibition of EZH2 in human KARPAS422 cells assessed as reduction in H3K27me3 level after 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50246927(CHEMBL4060447 | US10570121, Example 127)
Affinity DataIC50: 110nMAssay Description:Inhibition of EZH2 in human KARPAS422 cells assessed as reduction in H3K27me3 level after 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50246927(CHEMBL4060447 | US10570121, Example 127)
Affinity DataIC50: 16nMAssay Description:Inhibition of EZH2 in human KARPAS422 cells assessed as reduction in H3K27me3 level after 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details Article
PubMed
LigandPNGBDBM50246927(CHEMBL4060447 | US10570121, Example 127)
Affinity DataIC50: 892nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

LigandPNGBDBM50246927(CHEMBL4060447 | US10570121, Example 127)
Affinity DataIC50: 8nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

LigandPNGBDBM50246927(CHEMBL4060447 | US10570121, Example 127)
Affinity DataIC50: 165nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

LigandPNGBDBM50246927(CHEMBL4060447 | US10570121, Example 127)
Affinity DataIC50: 2.20nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50246927(CHEMBL4060447 | US10570121, Example 127)
Affinity DataKi:  0.200nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50246927(CHEMBL4060447 | US10570121, Example 127)
Affinity DataKi:  0.900nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50246927(CHEMBL4060447 | US10570121, Example 127)
Affinity DataKi:  56nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50246927(CHEMBL4060447 | US10570121, Example 127)
Affinity DataKi:  58nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent