BDBM50246285 CHEMBL519418::N4-((1R,2R)-2-(dimethylamino)cyclopentyl)-N2-(4-(methylsulfonyl)phenyl)-5-(trifluoromethyl)pyrimidine-2,4-diamine

SMILES CN(C)[C@@H]1CCC[C@H]1Nc1nc(Nc2ccc(cc2)S(C)(=O)=O)ncc1C(F)(F)F

InChI Key InChIKey=GEOPXFJNOXEGPU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50246285   

TargetFocal adhesion kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246285(N4-((1R,2R)-2-(dimethylamino)cyclopentyl)-N2-(4-(m...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of GST-tagged FAK assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246285(N4-((1R,2R)-2-(dimethylamino)cyclopentyl)-N2-(4-(m...)
Affinity DataIC50: 95nMAssay Description:Inhibition of GST-tagged pyk2 assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246285(N4-((1R,2R)-2-(dimethylamino)cyclopentyl)-N2-(4-(m...)
Affinity DataIC50: 95nMAssay Description:Inhibition of PYK2 assessed as reduction in peptide substrate phosphorylation by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246285(N4-((1R,2R)-2-(dimethylamino)cyclopentyl)-N2-(4-(m...)
Affinity DataIC50: 60nMAssay Description:Inhibition of PYK2 by PYK2-LI-COR cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246285(N4-((1R,2R)-2-(dimethylamino)cyclopentyl)-N2-(4-(m...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of purified activated FAK kinase domain (410-689) using ATP and Glu and Tyr random peptide polymer substrate by fluorescence polarization ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50246285(N4-((1R,2R)-2-(dimethylamino)cyclopentyl)-N2-(4-(m...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of human ERG by cell based by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed