BDBM50246236 5-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)indolin-2-one::CHEMBL487227

SMILES CN(C)[C@@H]1CCC[C@H]1Nc1nc(Nc2ccc3NC(=O)Cc3c2)ncc1C(F)(F)F

InChI Key InChIKey=IAHRSPNDVKURFK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50246236   

TargetFocal adhesion kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246236(5-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5...)
Affinity DataIC50: 810nMAssay Description:Inhibition of GST-tagged FAK assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246236(5-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5...)
Affinity DataIC50: 53nMAssay Description:Inhibition of GST-tagged pyk2 assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed