BDBM50246096 CHEMBL471526::N2-(1H-indazol-5-yl)-N4-(pyridin-2-ylmethyl)-5-(trifluoromethyl)pyrimidine-2,4-diamine

SMILES FC(F)(F)c1cnc(Nc2ccc3[nH]ncc3c2)nc1NCc1ccccn1

InChI Key InChIKey=OPWPQZXQSROBLU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50246096   

TargetFocal adhesion kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246096(N2-(1H-indazol-5-yl)-N4-(pyridin-2-ylmethyl)-5-(tr...)
Affinity DataIC50: 16nMAssay Description:Inhibition of GST-tagged FAK assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246096(N2-(1H-indazol-5-yl)-N4-(pyridin-2-ylmethyl)-5-(tr...)
Affinity DataIC50: 600nMAssay Description:Inhibition of GST-tagged pyk2 assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed