BDBM50245573 6-(2-(dimethylamino)ethyl)-9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione::CHEMBL519891

SMILES CN(C)CCn1c2ccc(O)cc2c2c3C(=O)NC(=O)c3c(cc12)-c1ccccc1

InChI Key InChIKey=GKROVVTVYGBAEB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50245573   

TargetSerine/threonine-protein kinase Chk1(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50245573(6-(2-(dimethylamino)ethyl)-9-hydroxy-4-phenylpyrro...)
Affinity DataIC50: 54nMAssay Description:Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determinationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50245573(6-(2-(dimethylamino)ethyl)-9-hydroxy-4-phenylpyrro...)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of c-SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetWee1-like protein kinase(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50245573(6-(2-(dimethylamino)ethyl)-9-hydroxy-4-phenylpyrro...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed