BDBM50244233 CHEMBL513067::trans-4-(((4-tert-butylcyclohexyl)(5-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)amino)methyl)-N-(1H-tetrazol-5-yl)benzamide

SMILES COc1ccc2n(C)c(nc2c1)N(Cc1ccc(cc1)C(=O)Nc1nnn[nH]1)[C@H]1CC[C@@H](CC1)C(C)(C)C

InChI Key InChIKey=QXZDLLBFWVISIF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50244233   

TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244233(trans-4-(((4-tert-butylcyclohexyl)(5-methoxy-1-met...)
Affinity DataIC50: 38nMAssay Description:Antagonist activity against human GCGR expressed in CHO cells assessed as glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPro-glucagon(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244233(trans-4-(((4-tert-butylcyclohexyl)(5-methoxy-1-met...)
Affinity DataIC50: 5.90E+3nMAssay Description:Binding affinity against human GLP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGastric inhibitory polypeptide(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244233(trans-4-(((4-tert-butylcyclohexyl)(5-methoxy-1-met...)
Affinity DataIC50: 2.50E+3nMAssay Description:Binding affinity against human GIPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244233(trans-4-(((4-tert-butylcyclohexyl)(5-methoxy-1-met...)
Affinity DataIC50: 4nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed