BDBM50243900 4-((4-(2-(Trifluoromethyl)-1H-benzo[d]imidazol-4-yl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole-2(3H)-thione::CHEMBL527422

SMILES FC(F)(F)c1nc2cccc(N3CCN(Cc4cccc5[nH]c(=S)[nH]c45)CC3)c2[nH]1

InChI Key InChIKey=LQBROJKIGRWRDQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50243900   

TargetGonadotropin-releasing hormone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243900(4-((4-(2-(Trifluoromethyl)-1H-benzo[d]imidazol-4-y...)
Affinity DataIC50: 580nMAssay Description:Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243900(4-((4-(2-(Trifluoromethyl)-1H-benzo[d]imidazol-4-y...)
Affinity DataIC50: 5.10E+4nMAssay Description:Displacement of [125I]-(D-Trp6)LHRH from rat recombinant GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243900(4-((4-(2-(Trifluoromethyl)-1H-benzo[d]imidazol-4-y...)
Affinity DataIC50: 3.40E+3nMAssay Description:Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed