BDBM50243854 2-(Trifluoromethyl)-4-(4-((2-(trifluoromethyl)-1Hbenzo[d]imidazol-4-yl)methyl)piperazin-1-yl)-1Hbenzo[d]imidazole::CHEMBL487627

SMILES FC(F)(F)c1nc2cccc(CN3CCN(CC3)c3cccc4nc([nH]c34)C(F)(F)F)c2[nH]1

InChI Key InChIKey=BEQHOOCNSMRQCI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50243854   

TargetGonadotropin-releasing hormone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243854(2-(Trifluoromethyl)-4-(4-((2-(trifluoromethyl)-1Hb...)
Affinity DataIC50: 9.50E+3nMAssay Description:Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243854(2-(Trifluoromethyl)-4-(4-((2-(trifluoromethyl)-1Hb...)
Affinity DataIC50: 2.10E+4nMAssay Description:Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243854(2-(Trifluoromethyl)-4-(4-((2-(trifluoromethyl)-1Hb...)
Affinity DataIC50: 6.40E+4nMAssay Description:Displacement of [125I]-(D-Trp6)LHRH from rat recombinant GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed