BDBM50243049 (S)-1-(5-(4-cyanophenyl)-3-(piperidin-3-ylcarbamoyl)thiophen-2-yl)urea::CHEMBL2070713::CHEMBL469481

SMILES NC(=O)Nc1sc(cc1C(=O)N[C@H]1CCCNC1)-c1ccc(cc1)C#N

InChI Key InChIKey=MNFQKQFALPLTFJ-UHFFFAOYSA-N

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50243049   

TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50243049((S)-1-(5-(4-cyanophenyl)-3-(piperidin-3-ylcarbamoy...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant CHK1 expressed in insect cells using biotinylaminohexanoyl-KKVSRSGLYRSPMPENLNRPR as substrate after 2 hrs by scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50243049((S)-1-(5-(4-cyanophenyl)-3-(piperidin-3-ylcarbamoy...)
Affinity DataEC50:  8nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin induced check pointMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50243049((S)-1-(5-(4-cyanophenyl)-3-(piperidin-3-ylcarbamoy...)
Affinity DataEC50:  1.70E+3nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as check point abrogationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50243049((S)-1-(5-(4-cyanophenyl)-3-(piperidin-3-ylcarbamoy...)
Affinity DataIC50: 6nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2-associated protein 1(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50243049((S)-1-(5-(4-cyanophenyl)-3-(piperidin-3-ylcarbamoy...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of Cdk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed