BDBM50242817 CHEMBL4087968::US20240150300, Compound Chidamide
SMILES Nc1ccc(F)cc1NC(=O)c1ccc(CNC(=O)\C=C\c2cccnc2)cc1
InChI Key InChIKey=WXHHICFWKXDFOW-UHFFFAOYSA-N
Data 42 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 42 hits for monomerid = 50242817
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant HDAC4 incubated for 17 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant human HDAC1 using SIRT1 as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by flu...More data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of recombinant human HDAC2 using FLUOR-DE-LYS-Green as substrate incubated for 10 mins followed by substrate addition and measured after 3...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+5nMAssay Description:Inhibition of human recombinant HDAC1 preincubated for 10 mins followed by addition of substrate fluor De Lys SIRT1 deacetylase measured after 30 min...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of human recombinant HDAC2 preincubated for 10 mins followed by addition of substrate fluor De Lys green measured after 30 mins by fluores...More data for this Ligand-Target Pair
TargetNuclear receptor corepressor 1(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: 1.80E+5nMAssay Description:Inhibition of human recombinant HDAC3/NCOR1 complex preincubated for 10 mins followed by addition of substrate fluor De Lys SIRT1 deacetylase measure...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human recombinant HDAC6 preincubated for 10 mins followed by addition of substrate fluor De Lys SIRT1 deacetylase measured after 30 min...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human recombinant HDAC8 preincubated for 10 mins followed by substrate addition measured after 30 mins by fluorescent plate reader anal...More data for this Ligand-Target Pair
Affinity DataIC50: 95nMAssay Description:Inhibition of human recombinant HDAC1 incubated for 17 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant HDAC2 incubated for 17 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of human recombinant HDAC3 incubated for 17 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant HDAC5 incubated for 17 hrsMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant HDAC6 incubated for 17 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant HDAC7 incubated for 17 hrsMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: 733nMAssay Description:Inhibition of human recombinant HDAC8 incubated for 17 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant HDAC9 incubated for 17 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 78nMAssay Description:Inhibition of human recombinant HDAC10 incubated for 17 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 432nMAssay Description:Inhibition of human recombinant HDAC11 incubated for 17 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 132nMAssay Description:Human recombinant HDAC family proteins with His and GST tags were expressed using insect baculovirus expression system, and a biologically active HDA...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Human recombinant HDAC family proteins with His and GST tags were expressed using insect baculovirus expression system, and a biologically active HDA...More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Institute of Pharmaceutical Industry
Curated by ChEMBL
Shanghai Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of recombinant human ERG expressed in HEK293 cells after 9 mins by patch clamp methodMore data for this Ligand-Target Pair
Affinity DataIC50: 864nMAssay Description:Inhibition of recombinant human HDAC1 using a fluorogenic substrate by fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 540nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys-Green as substrate preincubated for 5 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: 7.11E+3nMAssay Description:Inhibition of human recombinant HDAC6 using Fluor de Lys-Green as substrate preincubated for 5 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibition of HDAC in human HeLa cell extract using Fluor de Lys-Green as substrate preincubated for 5 mins followed by substrate addition and measur...More data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of human recombinant HDAC2 using Fluor de Lys-Green as substrate preincubated for 5 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using fluor-de-lys-green as substrate preincubated for 10 mins followed by substrate addition a...More data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant His-tagged HDAC1 (482 residues) expressed in baculovirus infected insect cells using FLUOR DE LYS SIRT1 as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibition of human recombinant His-tagged HDAC2 (1 to 582 residues) expressed in baculovirus infected insect cells using FLUOR DE LYS Green as subst...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: 7.23E+3nMAssay Description:Inhibition of human recombinant His-tagged HDAC6 expressed in baculovirus infected insect cells using FLUOR DE LYS SIRT1 as substrate preincubated fo...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of recombinant human HDAC1 expressed in Baculovirus insect cell expression system using [3H]-metabolically labeled acetylated histone subs...More data for this Ligand-Target Pair
Affinity DataIC50: 95nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 78nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant human His tagged HDAC1 expressed in baculovirus infected insect cells assessed as decrease in deacetylation of FLUOR DE LYS...More data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibition of recombinant human HDAC2 assessed as decrease in deacetylation of FLUOR DE LYS Green substrate preincubated for 10 mins followed by subs...More data for this Ligand-Target Pair
TargetNuclear receptor corepressor 1(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: 234nMAssay Description:Inhibition of recombinant human HDAC3/NCOR1 assessed as decrease in deacetylation of FLUOR DE LYS SIRT1 substrate preincubated for 10 mins followed b...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: 7.23E+3nMAssay Description:Inhibition of recombinant human His tagged HDAC6 expressed in baculovirus infected insect cells assessed as decrease in deacetylation of FLUOR DE LYS...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)
Curated by ChEMBL
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of recombinant human HDAC8 assessed as decrease in deacetylation of FLUOR DE LYS substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract assessed as decrease in deacetylation of FLUOR DE LYS Green substrate preincubated for 10 mins ...More data for this Ligand-Target Pair