BDBM50242631 CHEMBL4068366

SMILES NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCN(CC2)c2ccc(Cl)cc2)c1

InChI Key InChIKey=GGQAXNFSEUSJJE-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50242631   

TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
Mcdaniel College

Curated by ChEMBL
LigandPNGBDBM50242631(CHEMBL4068366)
Affinity DataIC50: 160nMAssay Description:Inhibition of full length recombinant His6-tagged PARP14 catalytic domain (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Mcdaniel College

Curated by ChEMBL
LigandPNGBDBM50242631(CHEMBL4068366)
Affinity DataIC50: 977nMAssay Description:Inhibition of recombinant human His6-tagged PARP5a catalytic domain (1091 to 1325 residues) expressed in Escherichia coli BL21(DE3) preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Mcdaniel College

Curated by ChEMBL
LigandPNGBDBM50242631(CHEMBL4068366)
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant human full length His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Mcdaniel College

Curated by ChEMBL
LigandPNGBDBM50242631(CHEMBL4068366)
Affinity DataIC50: 224nMAssay Description:Inhibition of recombinant human full length His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
Mcdaniel College

Curated by ChEMBL
LigandPNGBDBM50242631(CHEMBL4068366)
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Mcdaniel College

Curated by ChEMBL
LigandPNGBDBM50242631(CHEMBL4068366)
Affinity DataIC50: 900nMAssay Description:Inhibition of recombinant human His6-tagged PARP5a catalytic domain (1091 to 1325 residues) expressed in Escherichia coli BL21(DE3) preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
Mcdaniel College

Curated by ChEMBL
LigandPNGBDBM50242631(CHEMBL4068366)
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant human His6-tagged PARP14 catalytic/WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21(DE3) preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed