BDBM50241616 CHEMBL3347643

SMILES CCOc1cc(\C=C2\C(C)=NN(C2=O)c2ccccc2)cc(Cl)c1OCC(=O)OC

InChI Key InChIKey=RKKFQJXGAQWHBZ-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50241616   

TargetProtein Mdm4(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM50241616(CHEMBL3347643)
Affinity DataIC50: 847nMAssay Description:Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM50241616(CHEMBL3347643)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MDM2 in human U87MG cells assessed as reduction in MDM2 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2019
Entry Details Article
PubMed
TargetProtein Mdm4(Human)
University of Naples Federico II

Curated by ChEMBL
LigandPNGBDBM50241616(CHEMBL3347643)
Affinity DataKi:  780nMAssay Description:Binding affinity to MDMX (1 to 118 residues) (unknown origin) assessed as inhibition constant incubated for 1 hr measured by fluorescence polarizatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed