BDBM50241454 1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-enyl)-9H-xanthen-9-one::CHEMBL261706::beta-mangostin

SMILES [#6]-[#8]-c1cc2oc3cc(-[#8])c(-[#8]-[#6])c(-[#6]\[#6]=[#6](\[#6])-[#6])c3c(=O)c2c(-[#8])c1-[#6]\[#6]=[#6](\[#6])-[#6]

InChI Key InChIKey=OIFBLSRDNUZDSF-UHFFFAOYSA-N

Data  2 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50241454   

TargetFatty acid synthase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50241454(1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-...)
Affinity DataIC50: 2.48E+4nMAssay Description:Inhibition of FASMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetNuclear factor NF-kappa-B p105 subunit(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50241454(1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-...)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of p50 after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTranscription factor p65(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50241454(1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-...)
Affinity DataIC50: 1.21E+4nMAssay Description:Inhibition of nuclear factor NF-kappa-B p65 subunit after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSialidase(Clostridium perfringens)
Graduate School of Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50241454(1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-...)
Affinity DataIC50: 6.07E+4nMAssay Description:Inhibition of Clostridium perfringens neuraminidase by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetProbable maltase-glucoamylase 2(Human)
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50241454(1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-...)
Affinity DataIC50: 2.26E+4nMAssay Description:Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl alpha-D-glucoside as substrate preincubated for 0.5 hrs followed substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Minia University

Curated by ChEMBL
LigandPNGBDBM50241454(1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-...)
Affinity DataIC50: 1.89E+4nMAssay Description:Inhibition of human SIRT2 using sirtuin substrate incubated for 30 mins by enzymatic fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50241454(1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-...)
Affinity DataKi:  1.20E+4nMAssay Description:Competitive inhibition of IDH1-R132H mutant (unknown origin) using a-ketoglutarate and NADPH as substrate by steady state kinetic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2016
Entry Details Article
PubMed
TargetSialidase(Clostridium perfringens)
Graduate School of Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50241454(1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-...)
Affinity DataKi:  2.49E+4nMAssay Description:Competitive inhibition of Clostridium perfringens neuraminidase by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed