BDBM50241438 CHEMBL4065412
SMILES Nc1ccccc1NC(=O)c1ccc(Cn2cc(nn2)-c2ccc(cc2)C(=O)NCc2cccnc2)cc1
InChI Key InChIKey=LSGNVZAEAAZOEH-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50241438
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant HDAC1 (1 to 482 residues) expressed in Baculovirus using Ac-Leu-Gly-Lys(Ac)-AMC as substrate after 3 hrs by fluoresce...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant HDAC6 expressed in Baculovirus infected Sf9 cells using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 5 mins f...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GST tagged human recombinant HDAC4 (H86 to 31G) expressed in Baculovirus infected Sf9 insect cells using Ac-Leu-Gly-Lys(Tfa)-AMC as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GST tagged full length human recombinant HDAC8 (H90 to 30H) expressed in Baculovirus infected Sf9 insect cells using Ac-Leu-Gly-Lys(Tfa...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Inhibition of human recombinant HDAC1 (1 to 482 residues) expressed in Baculovirus using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
TargetNicotinamide phosphoribosyltransferase(Human)
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of human recombinant NAMPT using NAM as substrate preincubated for 5 mins followed by substrate addition measured after 15 mins by fluores...More data for this Ligand-Target Pair
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant HDAC2 (unknown origin) using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition mea...More data for this Ligand-Target Pair
Affinity DataIC50: 1.87E+3nMAssay Description:Inhibition of human recombinant HDAC3/GST tagged NCOR1 (397 to 503 residues) expressed in insect cells using Ac-Leu-Gly-Lys(Ac)-AMC as substrate prei...More data for this Ligand-Target Pair