BDBM50241438 CHEMBL4065412

SMILES Nc1ccccc1NC(=O)c1ccc(Cn2cc(nn2)-c2ccc(cc2)C(=O)NCc2cccnc2)cc1

InChI Key InChIKey=LSGNVZAEAAZOEH-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50241438   

TargetHistone deacetylase 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50241438(CHEMBL4065412)
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant HDAC1 (1 to 482 residues) expressed in Baculovirus using Ac-Leu-Gly-Lys(Ac)-AMC as substrate after 3 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2019
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50241438(CHEMBL4065412)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant HDAC6 expressed in Baculovirus infected Sf9 cells using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 5 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2019
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50241438(CHEMBL4065412)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GST tagged human recombinant HDAC4 (H86 to 31G) expressed in Baculovirus infected Sf9 insect cells using Ac-Leu-Gly-Lys(Tfa)-AMC as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2019
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50241438(CHEMBL4065412)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GST tagged full length human recombinant HDAC8 (H90 to 30H) expressed in Baculovirus infected Sf9 insect cells using Ac-Leu-Gly-Lys(Tfa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2019
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50241438(CHEMBL4065412)
Affinity DataIC50: 55nMAssay Description:Inhibition of human recombinant HDAC1 (1 to 482 residues) expressed in Baculovirus using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2019
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50241438(CHEMBL4065412)
Affinity DataIC50: 31nMAssay Description:Inhibition of human recombinant NAMPT using NAM as substrate preincubated for 5 mins followed by substrate addition measured after 15 mins by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2019
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50241438(CHEMBL4065412)
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant HDAC2 (unknown origin) using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2019
Entry Details Article
PubMed
TargetNuclear receptor corepressor 1(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50241438(CHEMBL4065412)
Affinity DataIC50: 1.87E+3nMAssay Description:Inhibition of human recombinant HDAC3/GST tagged NCOR1 (397 to 503 residues) expressed in insect cells using Ac-Leu-Gly-Lys(Ac)-AMC as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2019
Entry Details Article
PubMed