BDBM50240895 2-(1H-Imidazol-1-yl)-1-(4-nitrophenyl)ethanone::2-Imidazol-1-yl-1-(4-nitro-phenyl)-ethanone::CHEMBL162549

SMILES [O-][N+](=O)c1ccc(cc1)C(=O)Cn1ccnc1

InChI Key InChIKey=SBPGWXSTCFNGPY-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50240895   

TargetHeme oxygenase 2(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50240895(2-Imidazol-1-yl-1-(4-nitro-phenyl)-ethanone | 2-(1...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHeme oxygenase 1(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50240895(2-Imidazol-1-yl-1-(4-nitro-phenyl)-ethanone | 2-(1...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAromatase(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50240895(2-Imidazol-1-yl-1-(4-nitro-phenyl)-ethanone | 2-(1...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human aromatase preincubated with NADP+ for 10 mins before substrate addition measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Instituto De QuíMica MéDica

Curated by ChEMBL
LigandPNGBDBM50240895(2-Imidazol-1-yl-1-(4-nitro-phenyl)-ethanone | 2-(1...)
Affinity DataKi:  1.05E+5nMAssay Description:Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Mouse)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50240895(2-Imidazol-1-yl-1-(4-nitro-phenyl)-ethanone | 2-(1...)
Affinity DataKi: >5.00E+6nMAssay Description:Inhibition of C57BL/6 mouse eNOS assessed as conversion of oxyhemoglobin to methemoglobin by UV spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50240895(2-Imidazol-1-yl-1-(4-nitro-phenyl)-ethanone | 2-(1...)
Affinity DataKi:  1.05E+5nMAssay Description:Inhibition of rat recombinant nNOS expressed in baculovirus-infected Sf9 cells assessed as conversion of oxyhemoglobin to methemoglobin by UV spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed