BDBM50240348 (+)-dihydrokaempferol::(2R,3R)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one::CHEMBL9323::Dihydrokaempferol (diH-Kmp)

SMILES O[C@@H]1[C@H](Oc2cc(O)cc(O)c2C1=O)c1ccc(O)cc1

InChI Key InChIKey=PADQINQHPQKXNL-UHFFFAOYSA-N

Data  1 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50240348   

TargetAmyloid-beta precursor protein(Human)
Kyoto University

LigandPNGBDBM50240348((2R,3R)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-d...)
Affinity DataIC50: 5.00E+5nMpH: 7.4 T: 2°CAssay Description:Fluorescence intensity was measured at 420 nm excitation and 485 nm emission using a microplate reader (MPR-A4 II; TOSOH, Tokyo, Japan, or Fluoroskan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2017
Entry Details Article
PubMed
TargetPancreatic triacylglycerol lipase(Pig)
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM50240348((2R,3R)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-d...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of porcine pancreatic lipase pre-incubated for 15 mins before p-nitrophenylbutyrate substrate addition by microplate reader based methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50240348((2R,3R)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-d...)
Affinity DataIC50: 9.38E+4nMAssay Description:Inhibition of cow milk xanthine oxidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Kyoto Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50240348((2R,3R)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-d...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50240348((2R,3R)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-d...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Kyoto University

LigandPNGBDBM50240348((2R,3R)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-d...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) aggregation by Thioflavin-T fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Kyoto Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50240348((2R,3R)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-d...)
Affinity DataIC50: 7.36E+4nMAssay Description:Inhibition of monophenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-Tyrosine substrate by UV-Vis spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Kyoto Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50240348((2R,3R)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-d...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of diphenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-DOPA substrate by UV-Vis spectrophoto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Kyoto Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50240348((2R,3R)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-d...)
Affinity DataKi:  4.20E+4nMAssay Description:Competitive type inhibition of monophenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-Tyrosine substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed